Sentence comprehension in Lewy body diseases: a functional magnetic resonance imaging study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082252" target="_blank" >RIV/00159816:_____/25:00082252 - isvavai.cz</a>

Result on the web

<a href="https://academic.oup.com/braincomms/article/7/6/fcaf423/8307017" target="_blank" >https://academic.oup.com/braincomms/article/7/6/fcaf423/8307017</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/braincomms/fcaf423" target="_blank" >10.1093/braincomms/fcaf423</a>

Result language

angličtina

Original language name

Sentence comprehension in Lewy body diseases: a functional magnetic resonance imaging study

Original language description

Lewy body diseases, including Parkinson&apos;s disease and dementia with Lewy bodies, often involve mild cognitive impairment at diagnosis (mild cognitive impairment with Lewy bodies (MCI-LB). Language dysfunction in MCI-LB patients is often unrecognized. This study aimed to assess syntactic comprehension deficits in MCI-LB patients and to explore their neural correlates. A total of 25 MCI-LB patients (mean +/- sd: 72 +/- 5.6 years old, 10 women) and 25 healthy controls (HC, mean +/- sd: 66 +/- 4.0 years old, 12 women) performed task functional MRI Test of Sentence Comprehension (ToSC). Functional connectivity was analysed using psychophysiological interaction (PPI) method, focusing on the striatum and language networks. MCI-LB patients had lower ToSC scores than HC (MCI-LB: 74.7 +/- 15.7, HC: 88.5 +/- 9.0, P &lt; 0.001) and their PPI analysis revealed decreased connectivity from the striatum to the cuneus, precuneus, and left supramarginal gyrus, and reduced connectivity particularly in the dorsal pathway during noncanonical (syntactically more complex) sentence processing. Taken together, in this cross-sectional study MCI-LB patients showed impaired sentence comprehension related to decreased subcortical-cortical and dorsal language network connectivity. Specific changes in frontotemporal connectivity in MCI-LB might be a promising indicator of language related cognitive impairment in these a-synucleinopathies.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/LM2023049" target="_blank" >LM2023049: Czech National Node of the European Clinical Research Infrastructures Network</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain Communications

ISSN

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e-ISSN

2632-1297

Volume of the periodical

7

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

"fcaf423"

UT code for WoS article

001612350700001

EID of the result in the Scopus database

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