Noninvasive Temporal Interference Stimulation of the Subthalamic Nucleus in Parkinson's Disease Reduces Beta Activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082271" target="_blank" >RIV/00159816:_____/25:00082271 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00141107 RIV/00216305:26620/26:0197913
Result on the web
<a href="https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.30134" target="_blank" >https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.30134</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mds.30134" target="_blank" >10.1002/mds.30134</a>
Alternative languages
Result language
angličtina
Original language name
Noninvasive Temporal Interference Stimulation of the Subthalamic Nucleus in Parkinson's Disease Reduces Beta Activity
Original language description
Background: Temporal interference stimulation (TIS) is a novel noninvasive electrical stimulation technique to focally modulate deep brain regions; a minimum of two high-frequency signals (f(1) and f(2) > 1 kHz) interfere to create an envelope-modulated signal at a deep brain target with the frequency of modulation equal to the difference frequency: Delta f = |f(2) - f(1)|. Objective: The goals of this study were to verify the capability of TIS to modulate the subthalamic nucleus (STN) with Delta f and to compare the effect of TIS and conventional deep brain stimulation (DBS) on the STN beta oscillations in patients with Parkinson's disease (PD). Methods: DBS leads remained externalized after implantation, allowing local field potentials (LFPs) recordings in eight patients with PD. TIS was performed initially by two pairs (f(1) = 9.00 kHz; f(2) = 9.13 kHz, 4 mA peak-peak per pair maximum) of scalp electrodes placed in temporoparietal regions to focus the envelope signal maximum (Delta f = 130 Hz) at the motor part of the STN target. Results: The comparison between the baseline LFPs and recordings after TIS and conventional DBS sessions showed substantial suppression of high beta power peak after both types of stimulation in all patients. Conclusions: TIS has the potential to effectively modulate the STN and reduce the beta oscillatory activity in a completely noninvasive manner, as is traditionally possible only with intracranial DBS. Future studies should confirm the clinical effectiveness of TIS and determine whether TIS could be used to identify optimal DBS candidates and individualize DBS targets. (c) 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Movement disorders
ISSN
0885-3185
e-ISSN
1531-8257
Volume of the periodical
40
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1051-1060
UT code for WoS article
001462992200001
EID of the result in the Scopus database
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