Noninvasive deep brain stimulation of subthalamic nucleus in Parkinson's disease: temporal and spatial properties

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00142760" target="_blank" >RIV/00216224:14110/25:00142760 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Noninvasive deep brain stimulation of subthalamic nucleus in Parkinson's disease: temporal and spatial properties

Original language description

Background and aims: Temporal Interference stimulation (TIS) is a novel non- invasive brain electrical stimulation technique that has a potential to modulate deep brain regions. The focal modulation of TIS is possible using two high frequency signals (&gt;1kHz), which interfere to create low frequency envelope modulating the target area. Recent work presented the capability of TIS to focus the subthalamic nucleus (STN) and to suppress STN beta oscillations in Parkinson's disease. Here, we present temporal and spatial characteristics of this modulation technique. Methods: Implanted DBS leads were temporally externalized for local field potentials (LFP) recording in 8 patients with Parkinson's disease indicated for STN- DBS. STN- TIS was performed by 2 pairs (f1 = 9.00kHz; f2 = 9.13kHz, 2mA per pair max.) of scalp electrodes placed in frontoparietal regions for 3 minutes. The following 3 minutes of resting- state were then used for LFP evaluation. Results: Suppressed beta activity in STN re- occurred back in approx. 120 seconds for STN- TIS. In control condition, where conventional DBS was used, the after- effect varied across group and in some patients was more immediate than TIS. No electrical field enhancement around the DBS lead was found in case of transcranial TIS. Conclusion: TIS is a different type of neuromodulation, applied in a sinusoidal pattern at a sub- threshold intensity; DBS is a pulsed pattern supra- threshold intensity stimulation that generates action potentials. Despite these different mechanisms of action there is growing evidence that TIS has the potential to influence deep brain oscillatory activity and induce clinical effects in a way similar to DBS.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů