Camptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cells.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F11%3A10105084" target="_blank" >RIV/00179906:_____/11:10105084 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/11:10105084
Result on the web
<a href="http://www.springerlink.com/content/j763775826255700/fulltext.pdf" target="_blank" >http://www.springerlink.com/content/j763775826255700/fulltext.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10495-011-0635-8" target="_blank" >10.1007/s10495-011-0635-8</a>
Alternative languages
Result language
angličtina
Original language name
Camptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cells.
Original language description
Various DNA-targeting agents may initiate p53-dependent as well as p53-independent response and subsequent apoptosis via alternative cellular systems which include for instance p73, caspase-2 or Bcl-2 family proteins. The scope of involvement of individual molecules in this process and the mechanisms governing their potential interplay are still not entirely understood, in particular in highly aggressive cancers such as in malignant melanoma. In this work we investigated the role and involvement of bothp53-dependent and -independent mechanisms in selected melanoma cell lines with differing status of p53 using a model DNA topoisomerase I inhibitor camptothecin (CPT). Here we report that CPT induced in Bowes melanoma cells apoptosis which is essentiallyp53 and mitochondria-dependent but with some involvement of caspase-2 and p73. Conversely, in mutant p53 melanoma cells overall levels of CPT-induced apoptosis are significantly lower, with p73 and caspase-2 signaling playing important r
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Apoptosis : an international journal on programmed cell death
ISSN
1360-8185
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
11
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
12
Pages from-to
1165-1176
UT code for WoS article
000300093600008
EID of the result in the Scopus database
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