The role of the TP73 gene and its transcripts in neuro-oncology
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00077492" target="_blank" >RIV/00216224:14110/14:00077492 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/14:00061124
Result on the web
<a href="http://dx.doi.org/10.3109/02688697.2014.908162" target="_blank" >http://dx.doi.org/10.3109/02688697.2014.908162</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/02688697.2014.908162" target="_blank" >10.3109/02688697.2014.908162</a>
Alternative languages
Result language
angličtina
Original language name
The role of the TP73 gene and its transcripts in neuro-oncology
Original language description
Protein p73 is a member of the p53 protein family that can induce cell cycle arrest or apoptosis by the activation of p53-responsive genes as well as p53-independent pathways. Alternative promoter usage, together with differential splicing of the C-terminal exons, forms several distinct mRNAs that are translated into corresponding protein isoforms containing different domains. While TAp73 isoforms respond to genotoxic stress in a manner similar to tumor suppressor p53, Delta TAp73 isoforms inhibit apoptosis during normal development and in cancer cell lines. Thus, the impact of p73 on tumorigenesis depends on a subtle balance between tumor-promoting and-suppressing isoforms. Due to the structural homology between p53 and p73, a subtle balance among p53family members and their isoforms could influence glioma cell evolution toward malignancy. Thus, the p73 status has to be considered when studying the regulatory role of p53 protein in gliomagenesis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British journal of neurosurgery
ISSN
0268-8697
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
598-605
UT code for WoS article
000341753500004
EID of the result in the Scopus database
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