Overexpression of the ?Np73 isoform is associated with centrosome amplification in brain tumor cell lines

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A%230000654" target="_blank" >RIV/00209805:_____/15:#0000654 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs13277-015-3474-3" target="_blank" >http://link.springer.com/article/10.1007%2Fs13277-015-3474-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13277-015-3474-3" target="_blank" >10.1007/s13277-015-3474-3</a>

Result language
angličtina
Original language name
Overexpression of the ?Np73 isoform is associated with centrosome amplification in brain tumor cell lines
Original language description
The p73 protein is a member of the p53 family, and this protein is known to be essential for the maintenance of genomic stability, DNA repair, and apoptosis regulation. Transcription from two promoters leads to two main N-terminal isoforms: the TAp73 isoform is reported to have tumor suppressor function, whereas the ?Np73 isoform likely has oncogenic potential. The present study is focused on the investigation of a possible role of both these p73 N-terminal isoforms in the process of centrosome amplification. HGG-02 and GM7 glioblastoma cell lines and the Daoy medulloblastoma cell line were used in this study. The cells were analyzed using indirect immunofluorescence to determine TAp73 and ?Np73 expression patterns and possible co-localization with theBubR1 protein, as well as the number of centrosomes. A transiently transfected GM7 cell line was used to verify the results concerning the N-terminal isoforms in relation to centrozome amplification. We found that increased immunoreactiv
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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