SAR Study on Reactivators of Ethyl-Paraoxon Inhibited Acetylcholinesterase

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10124634" target="_blank" >RIV/00179906:_____/12:10124634 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/12:43874561 RIV/00216208:11160/12:10124634

Result on the web

<a href="http://www.benthamdirect.org/pages/b_viewarticle.php?articleID=3177425" target="_blank" >http://www.benthamdirect.org/pages/b_viewarticle.php?articleID=3177425</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

SAR Study on Reactivators of Ethyl-Paraoxon Inhibited Acetylcholinesterase

Original language description

The current treatment of organophosphorus compounds induced intoxication consists of combined administration of anticholinergic drug, oxime reactivator and anticonvulsant. Oxime reactivators are causal treatment of organophosphorus intoxication and theyare able to cleave OP moiety from the molecule of inhibited acetylcholinesterase. Unfortunately, none of the currently used oximes is sufficiently effective against all nerve agents and pesticides. Thus, finding of new potent acetylcholinesterase reactivators is necessary. In this study, the reactivation efficacy of three series of novel bisquaternary reactivators with prop-1,3-diyl, but-1,4-diyl and but-2-ene-1,4-diyl linker against paraoxon inhibited acetylcholinesterase in vitro is presented. The obtained results were compared to the commercially used reactivators (pralidoxime, trimedoxime, obidoxime, methoxime, asoxime). Some newly prepared compounds showed promising ability of paraoxon in vitro reactivation, even in human attainabl

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/ME09086" target="_blank" >ME09086: Development of novel antidotal treatment against organophosphorus pesticides</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Letters in Drug Design and Discovery

ISSN

1570-1808

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

6

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

587-594

UT code for WoS article

000308697100005

EID of the result in the Scopus database

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