All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F16%3AA1801RWQ" target="_blank" >RIV/61988987:17110/16:A1801RWQ - isvavai.cz</a>

  • Alternative codes found

    RIV/00179906:_____/16:10330207 RIV/60162694:G44__/16:43875688 RIV/62690094:18470/16:50005166

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s00204-016-1827-3" target="_blank" >http://dx.doi.org/10.1007/s00204-016-1827-3</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00204-016-1827-3" target="_blank" >10.1007/s00204-016-1827-3</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides

  • Original language description

    Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many failures in living organism and ultimately in death. Organophosphorus compounds developed as nerve agents such as tabun, sarin, soman, VX and others belong to the most toxic chemical warfare agents and are one of the biggest threats to the modern civilization. Moreover, misuse of nerve agents together with organophosphorus pesticides (e.g. malathion, paraoxon, chlorpyrifos, etc.) which are annually implicated in millions of intoxications and hundreds of thousand deaths reminds us of insufficient protection against these compounds. Basic treatments for these intoxications are based on immediate administration of atropine and acetylcholinesterase reactivators which are currently represented by mono- or bis-pyridinium aldoximes. However, these antidotes are not sufficient to ensure 100 % treatment efficacy even they are administered immediately after intoxication, and in general, they possess several drawbacks. Herein, we have reviewed new efforts leading to the development of novel reactivators and proposition of new promising strategies to design novel and effective antidotes. Structure-activity relationships and biological activities of recently proposed acetylcholinesterase reactivators are discussed and summarized. Among further modifications of known oximes, the main attention has been paid to dual binding site ligands of AChE as the current mainstream strategy. We have also discussed new chemical entities as potential replacement of oxime functional group.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30108 - Toxicology

Result continuities

  • Project

    <a href="/en/project/GA15-16701S" target="_blank" >GA15-16701S: Concept of non-quaternary reactivators AChE as the antidotes of organophsophorus poisoning - a new hope or a blind way?</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    ARCHIVES OF TOXICOLOGY

  • ISSN

    0340-5761

  • e-ISSN

    1432-0738

  • Volume of the periodical

    90

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    29

  • Pages from-to

    2831-2859

  • UT code for WoS article

    000387697600001

  • EID of the result in the Scopus database

    2-s2.0-84984788964