Reactivators of tabun-inhibited acetylcholinesterase: structure-biological activity relationship

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F07%3A00001675" target="_blank" >RIV/60162694:G44__/07:00001675 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Reactivators of tabun-inhibited acetylcholinesterase: structure-biological activity relationship
Original language description
Acetylcholinesterase (AChE; EC 3.1.1.7) reactivators (called oximes) are important group of drugs used as antidotes in the treatment of intoxications with highly toxic organophosphorus compounds such as pesticides (paraoxon, chlorpyrifos etc.) and nerveagents (sarin, tabun etc.). After the sarin terroristic attack in Tokyo subway, their development employed many scientists from both - military and civilian-sectors. Due to the rapid synthesis and evaluation of the biological activity of many new structurally different potential antidotes in our laboratories, we would like to discuss relationship between the structure of currently available AChE reactivators and their biological activity. There is a wide range of organophosphorus nerve agents and pesticides and, therefore, our article was focused on reactivators of tabun-inhibited AChE only. This agent was chosen for its poor ability of currently commercially available oximes to reactivate AChE inhibited by this nerve agent.Presented re
Czech name
Reaktivátory tabunem-inhibované AChE : vztah struktura-biologická aktivita
Czech description
Byly diskutovány strukturní vlastnosti reaktivátorů tabunem-inhibované AChE.

Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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