The effect of levetiracetam on rat bone mass, structure and metabolism
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10173388" target="_blank" >RIV/00179906:_____/13:10173388 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/13:10173388
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0920121113002179" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0920121113002179</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.eplepsyres.2013.08.012" target="_blank" >10.1016/j.eplepsyres.2013.08.012</a>
Alternative languages
Result language
angličtina
Original language name
The effect of levetiracetam on rat bone mass, structure and metabolism
Original language description
Epilepsy is a condition affecting 0,5 - 1% of the population in developed countries. Antiepileptic drugs can adversely affect bone health. We report our findings in orchidectomised rats fed on levetiracetam-enriched diet for 12 weeks concerning the impact of levetiracetam (LEV) on bone markers, bone mineral density (BMD) and biomechanical properties. Compared to the control group we found lower fat mass, lower BMD in the area of the left femur, lower BMC (bone mineral content) in both femur a reduced OPG (osteoprotegerin), and an increased concentration CTX-I (corboxy-terminal cross-linking telopeptide of type I collagen) of borderline statistical significance. Our results suggest that in the ORX-rat model LEV may affect bone mass of the femoral diaphysis (cortical bone) and suggest that LEV may suppress bone turnover. We may assume that the reduction in serum OPG levels could be explained by the inhibition of osteoblast activity. But further studies in animals and humans will be neede
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Epilepsy Research
ISSN
0920-1211
e-ISSN
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Volume of the periodical
107
Issue of the periodical within the volume
1-2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
56-60
UT code for WoS article
000328524800006
EID of the result in the Scopus database
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