Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10272005" target="_blank" >RIV/00179906:_____/14:10272005 - isvavai.cz</a>

Alternative codes found

RIV/62690094:18450/14:50002388 RIV/62690094:18470/14:50002388

Result on the web

<a href="http://link.springer.com/article/10.1007%2Fs00204-014-1312-9" target="_blank" >http://link.springer.com/article/10.1007%2Fs00204-014-1312-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00204-014-1312-9" target="_blank" >10.1007/s00204-014-1312-9</a>

Result language

angličtina

Original language name

Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences

Original language description

Aflatoxins are potent hepatocarcinogen in animal models and suspected carcinogen in humans. The most important aflatoxin in terms of toxic potency and occurrence is aflatoxin B1 (AFB1). In this review, we mainly summarized the key metabolizing enzymes ofAFB1 in animals and humans. Moreover, the interindividual and the interspecies differences in AFB1 metabolism are highly concerned. In human liver, CYP3A4 plays an important role in biotransforming AFB1 to the toxic product AFB1-8,9-epoxide. In human lung, CYP2A13 has a significant activity in metabolizing AFB1 to AFB1-8,9-epoxide and AFM1-8,9-epoxide. The epoxide of AFB1-8,9-epoxide could conjugate with glutathione to reduce the toxicity by glutathione-S-transferase (GST). In poultry species, CYP2A6,CYP3A37, CYP1A5, and CYP1A1 are responsible for bioactivation of AFB1. There are interindividual variations in the rate of activation of aflatoxins in various species, and there are also differences between children and adults. The age an

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archives of Toxicology

ISSN

0340-5761

e-ISSN

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Volume of the periodical

88

Issue of the periodical within the volume

9

Country of publishing house

DE - GERMANY

Number of pages

10

Pages from-to

1635-1644

UT code for WoS article

000340585900002

EID of the result in the Scopus database

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