A New Concept in the Separation of Polyethyleneglycol-Modified PAMAM Dendrons by Liquid Chromatography
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10281336" target="_blank" >RIV/00179906:_____/14:10281336 - isvavai.cz</a>
Alternative codes found
RIV/62690094:18470/14:50002316 RIV/44555601:13440/14:43885504
Result on the web
<a href="http://dx.doi.org/10.1093/chromsci/bmt032" target="_blank" >http://dx.doi.org/10.1093/chromsci/bmt032</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/chromsci/bmt032" target="_blank" >10.1093/chromsci/bmt032</a>
Alternative languages
Result language
angličtina
Original language name
A New Concept in the Separation of Polyethyleneglycol-Modified PAMAM Dendrons by Liquid Chromatography
Original language description
In this work, a unique high-performance liquid chromatographic method was developed and applied for monitoring the synthesis of polyethyleneglycol surface modified poly(amidoamine) cystamine core dendrimers (PEG-PAMAMs) and PEG-PAMAM-alkynes with a single alkyne moiety attached to the core of a dendron through a unique sulfhydryl group. The separation of the products was performed on a column with a pentafluorphenylpropyl stationary phase, allowing multiple mechanisms of selectivity. More than 50 peakswere separated in one run, reflecting the degree of dendrimer PEGylation (PEG average molecular mass: 3,000). Moreover, modification of PAMAM with a single alkyne group could be distinguished. The developed method can be used for the general characterization and separation of PAMAM derivatives, in which the degree of modification is critical for final applications.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Chromatographic Science
ISSN
0021-9665
e-ISSN
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Volume of the periodical
52
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
321-328
UT code for WoS article
000342734400006
EID of the result in the Scopus database
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