Synthesis of new anionic carbosilane dendrimers via thiol-ene chemistry and their antiviral behaviour
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F14%3A43885809" target="_blank" >RIV/44555601:13440/14:43885809 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/c4ob00162a" target="_blank" >http://dx.doi.org/10.1039/c4ob00162a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c4ob00162a" target="_blank" >10.1039/c4ob00162a</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of new anionic carbosilane dendrimers via thiol-ene chemistry and their antiviral behaviour
Original language description
A synthetic strategy has been developed for the preparation of anionic carbosilane dendrimers bearing sulfonate or carboxylate groups at their periphery by means of thiol-ene chemistry. It offers significant advantages, such as milder reaction conditions, shorter reaction times and more facile purification methods, when compared with other synthetic protocols used previously, e.g. hydrosilylation followed by a Michael-type addition or azide-alkyne coupling reactions. Molecular dynamics simulations of the second generation anionic dendrimers addressing shape and size effects of the terminal groups and conformational variability indicated that the core eccentricity and flexibility might need to be taken into account for toxicity and interaction with viral and/or cellular receptors, respectively. The biocompatibility of anionic carbosilane dendrimers has been explored showing differences between silicon-cored and polyphenoxo-cored dendrimers. In addition, silicon-cored dendrimers achieved
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GA13-06989S" target="_blank" >GA13-06989S: Plasma-chemical modification of phyllosilicates for functional nanostructures</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Organic & Biomolecular Chemistry
ISSN
1477-0520
e-ISSN
—
Volume of the periodical
12
Issue of the periodical within the volume
20
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
3222-3237
UT code for WoS article
000335336800010
EID of the result in the Scopus database
—