Comparative Lipophilicity of Morphine Derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F15%3A10295155" target="_blank" >RIV/00179906:_____/15:10295155 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1556/JPC.28.2015.2.7" target="_blank" >http://dx.doi.org/10.1556/JPC.28.2015.2.7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1556/JPC.28.2015.2.7" target="_blank" >10.1556/JPC.28.2015.2.7</a>

Result language
angličtina
Original language name
Comparative Lipophilicity of Morphine Derivatives
Original language description
Lipophilicity is an important physicochemical characteristic of compounds having potential use in the treatment of humans and animals. Morphine and its semisynthetic derivatives have effects on mu (mu), kappa (kappa), and delta (delta) opioid receptors, and their physiological, pharmacological, and therapeutic effects mainly depend on their distribution in the body. The progress in separation techniques has made it possible to use modern methods to determine lipophilic/hydrophilic character of small amounts of organic compounds in just a few minutes. In addition to the classical determination of lipophilicity (shaken-flask method), other experimental methods (such as reversed-phase thin-layer chromatography, distribution-pH profile, etc.) and calculations based on the molecular composition are widely used. The lipophilic character of several morphine derivatives was determined using reversed-phase thin-layer chromatography and also high-performance liquid chromatography (HPLC) method. The results are graphically compared. Lipophilicity (log P) calculation using Pallas 3.8 program was successful only for certain morphine derivatives. Parameters derived from the experimental results of reversed-phase thin-layer chromatography and those of a special HPLC column were well comparable.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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