Laboratory-Based Markers as Predictors of Brain Infarction During Carotid Stenting: a Prospective Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10328053" target="_blank" >RIV/00179906:_____/16:10328053 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10328053 RIV/00216208:11150/16:10328053 RIV/61989592:15120/16:33159205 RIV/00843989:_____/16:E0105487 RIV/61988987:17110/16:A210288V

Result on the web

<a href="https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_31799/_pdf" target="_blank" >https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_31799/_pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5551/jat.31799" target="_blank" >10.5551/jat.31799</a>

Result language

angličtina

Original language name

Laboratory-Based Markers as Predictors of Brain Infarction During Carotid Stenting: a Prospective Study

Original language description

Aim: New ischemic lesions in the brain can be detected in approximately 50% of patients undergoing carotid artery stenting (CAS). We wished to discover the laboratory-based predictors of new infarctions in the brain after CAS. Methods: All consecutive patients with internal carotid artery stenosis of >= 70% with indication for CAS were enrolled in a prospective study for 16 months. All patients used dual antiplatelet therapy for >= 7 days before CAS. Neurologic examination and magnetic resonance imaging (MRI) of the brain were undertaken before and at 24 h after CAS. Samples of venous blood were collected at <24 h before CAS for the evaluation of hematology, reticulocytes, coagulation markers (PT, APTT, Fbg, Clauss), vWF antigen, PAI-1 activity, PAI-1 polymorphism 4G/5G, and the multiplate (aspirin and clopidogrel) resistance test. Blood samples for the assessment of anti-Xa activity were collected during CAS. Differences in the values of laboratory markers between patients with and without new ischemic lesions of the brain on control MRI were evaluated. Results: The cohort comprised 81 patients (53 males; mean age, 67.3 +/- 7.2 years). New ischemic infarctions in the brain on control MRI were found in 46 (56.8%) patients. Three of seven patients with resistance to aspirin or clopidogrel had a new ischemic infarction in the brain. No significant differences for particular markers were found between patients with and without an ischemic lesion in the brain. Conclusion: A high risk of a new ischemic infarction in the brain was detected in patients undergoing CAS, but a laboratory-based predictor of such an infarction could not be identified.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of atherosclerosis and thrombosis

ISSN

1340-3478

e-ISSN

—

Volume of the periodical

23

Issue of the periodical within the volume

7

Country of publishing house

JP - JAPAN

Number of pages

9

Pages from-to

839-847

UT code for WoS article

000384912100011

EID of the result in the Scopus database

2-s2.0-84976643792