Risk reduction of brain infarction during carotid endarterectomy or stenting using sonolysis - prospective randomized study pilot data

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F12%3A00102840" target="_blank" >RIV/00843989:_____/12:00102840 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1063/1.4769951" target="_blank" >http://dx.doi.org/10.1063/1.4769951</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1063/1.4769951" target="_blank" >10.1063/1.4769951</a>

Result language
angličtina
Original language name
Risk reduction of brain infarction during carotid endarterectomy or stenting using sonolysis - prospective randomized study pilot data
Original language description
Sonolysis is a new therapeutic option for the acceleration of arterial recanalization. The aim of this study was to confirm risk reduction of brain infarction during endarterectomy (CEA) and stenting (CAS) of the internal carotid artery (ICA) using sonolysis with continuous transcranial Doppler (TCD) monitoring by diagnostic 2 MHz probe, additional interest was to assess impact of new brain ischemic lesions on cognitive functions. Methods: All consecutive patients 1/ with ICA stenosis >70%, 2/ indicatedto CEA or CAS, 3/ with signed informed consent, were enrolled to the prospective study during 17 months. Patients were randomized into 2 groups: Group 1 with sonolysis during intervention and Group 2 without sonolysis. Neurological examination, assessment of cognitive functions and brain magnetic resonance imaging (MRI) were performed before and 24 hours after intervention in all patients. Occurrence of new brain infarctions (including infarctions >0.5 cm3), and the results of Mini-Ment
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/NT11386" target="_blank" >NT11386: Risk reduction of symptomatic and silent brain infarctions during carotid endarterectomy and carotid stenting due to ultrasound activation of endogenous fibrinolytic system using transcranial Doppler monitoring</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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