Sonolysis in prevention of brain infarction during carotid endarterectomy and stenting (SONOBUSTER): a randomized, controlled trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F16%3AE0105650" target="_blank" >RIV/00843989:_____/16:E0105650 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/16:33155427 RIV/61989592:15120/16:33155427 RIV/61383082:_____/16:00000239 RIV/61988987:17110/16:A210288O

Result on the web

<a href="http://dx.doi.org/10.1093/eurheartj/ehv492" target="_blank" >http://dx.doi.org/10.1093/eurheartj/ehv492</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/eurheartj/ehv492" target="_blank" >10.1093/eurheartj/ehv492</a>

Result language

angličtina

Original language name

Sonolysis in prevention of brain infarction during carotid endarterectomy and stenting (SONOBUSTER): a randomized, controlled trial

Original language description

AIMS: Previous case series have detected silent brain infarctions in as many as one-third of patients after carotid endarterectomy (CEA) and in up to two-thirds of patients after carotid angioplasty and stenting (CAS). Sonolysis employs ultrasound to facilitate disruption of thrombi and has been shown to be safe and effective for improving long-term outcomes following acute stroke. Here, we examined whether intraoperative sonolysis alters the risk of new brain ischaemic lesions during CEA or CAS. METHODS AND RESULTS: All consecutive patients with internal carotid stenosis ?70% indicated for CEA/CAS were screened in this prospective study. Patients were allocated randomly to sonolysis and control groups. Neurological examination, cognitive function tests, and brain magnetic resonance imaging (MRI) were conducted before intervention and at 24 and 30 days post-surgery. Of the 487 screened patients, 121 (87 males; mean age, 66.65 ± 7.17 years) were allocated to the sonolysis group and 121 (75; 66.02 ± 8.11 years) to the control group. New brain ischaemic lesions on post-procedure MRI were significantly less frequent in the sonolysis group than in the control group (31.4% of patients vs. 47.1%; P = 0.018). Sonolysis and CEA were identified as independent predictors of reduced brain ischaemic risk [sonolysis: odds ratio (OR) = 0.450 (0.215-0.942), P = 0.034 and CEA: OR = 0.208 (0.087-0.495), P < 0.001]. Stroke or transient ischaemic attack occurred in one sonolysis patient and three control patients (P = 0.372). No significant group differences were found in post-intervention cognitive test scores (P > 0.3). CONCLUSION: This study provides Class II evidence that sonolysis during CEA or CAS reduces the risk of new brain ischaemic lesions.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NT11386" target="_blank" >NT11386: Risk reduction of symptomatic and silent brain infarctions during carotid endarterectomy and carotid stenting due to ultrasound activation of endogenous fibrinolytic system using transcranial Doppler monitoring</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Heart Journal

ISSN

0195-668X

e-ISSN

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Volume of the periodical

37

Issue of the periodical within the volume

n. 40

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

"p. 3096-3102"

UT code for WoS article

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EID of the result in the Scopus database

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