Proteomic analysis of cerebrospinal fluid for relapsing-remitting multiple sclerosis and clinically isolated syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10332673" target="_blank" >RIV/00179906:_____/16:10332673 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/16:00093167 RIV/00216208:11150/16:10332673 RIV/65269705:_____/16:00066243
Result on the web
<a href="http://dx.doi.org/10.3892/br.2016.668" target="_blank" >http://dx.doi.org/10.3892/br.2016.668</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/br.2016.668" target="_blank" >10.3892/br.2016.668</a>
Alternative languages
Result language
angličtina
Original language name
Proteomic analysis of cerebrospinal fluid for relapsing-remitting multiple sclerosis and clinically isolated syndrome
Original language description
Early diagnosis and treatment of multiple sclerosis (MS) in the initial stages of the disease can significantly retard its progression. The aim of the present study was to identify changes in the cerebrospinal fluid proteome in patients with relapsing-remitting MS and clinically isolated MS syndrome who are at high risk of developing MS (case group) compared to healthy population (control) in order to identify potential new markers, which could ultimately aid in early diagnosis of MS. The protein concentrations of each of the 11 case and 15 control samples were determined using a bicinchoninic acid assay. Nanoscale liquid chromatography coupled with tandem mass spectrometry was used for protein identification. Proteomics data were processed using the Perseus software suite and R. The results were filtered using the Benjamini-Hochberg procedure for the false discovery rate (FDR) correction (FDR<0.05). The results showed that, 26 proteins were significantly dysregulated in case samples compared to the controls. Nine proteins were found to be significantly less abundant in case samples, while the abundance of 17 proteins was significantly increased in case samples compared to controls. Three of the proteins were previously linked to RR MS, including immunoglobulin (Ig) gamma-1 chain C region, Ig heavy chain V-III region BRO and Ig kappa chain C region. Three proteins that were uniquely expressed in patients with RR MS were identified and these proteins may serve as prognostic biomarkers for identifying patients with a high risk of developing RR MS.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Reports
ISSN
2049-9434
e-ISSN
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Volume of the periodical
5
Issue of the periodical within the volume
1
Country of publishing house
GR - GREECE
Number of pages
6
Pages from-to
35-40
UT code for WoS article
000379957300007
EID of the result in the Scopus database
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