Amniotic fluid calreticulin in pregnancies complicated by the preterm prelabor rupture of membranes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10332847" target="_blank" >RIV/00179906:_____/16:10332847 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/16:10332847 RIV/00843989:_____/16:E0105615

Result on the web

<a href="http://dx.doi.org/10.3109/14767058.2016.1154940" target="_blank" >http://dx.doi.org/10.3109/14767058.2016.1154940</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/14767058.2016.1154940" target="_blank" >10.3109/14767058.2016.1154940</a>

Result language

angličtina

Original language name

Amniotic fluid calreticulin in pregnancies complicated by the preterm prelabor rupture of membranes

Original language description

Objective: This study aimed to determine the amniotic fluid calreticulin concentrations in women with the preterm prelabor rupture of membranes (PPROM) based on the microbial invasion of the amniotic cavity (MIAC), intraamniotic inflammation (IAI) and microbial-associated IAI.Methods: One hundred sixty-eight women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis and were assayed for calreticulin concentrations by ELISA. IAI was defined as an amniotic fluid interleukin-6 concentration>745pg/ml. Microbial-associated IAI was defined as the presence of both MIAC and IAI.Result: Women with MIAC (with MIAC: median 54.4ng/ml, versus without MIAC: median 32.6ng/ml; p<0.0001), IAI (with IAI: median 66.8ng/ml, versus without IAI: median 33.0ng/ml; p<0.0001) and microbial-associated IAI (with microbial-associated IAI: median 82.5ng/ml, versus without microbial-associated IAI: median 33.7ng/ml; p<0.0001) had higher concentrations of calreticulin than women without these complications. An amniotic fluid calreticulin concentration of 81.4ng/ml was found to be the best cutoff point for identifying women with microbial-associated IAI.Conclusions: The presence of microbial-associated IAI is associated with increased amniotic fluid calreticulin concentrations. Calreticulin seems to be a promising marker for the early identification of PPROM complicated by microbial-associated IAI.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

The Journal of Maternal-Fetal &amp; Neonatal Medicine

ISSN

1476-7058

e-ISSN

—

Volume of the periodical

29

Issue of the periodical within the volume

24

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

3921-3929

UT code for WoS article

000384680900001

EID of the result in the Scopus database

2-s2.0-84961211039