Feasibility of atlas-based active bone marrow sparing intensity modulated radiation therapy for cervical cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F17%3A10367303" target="_blank" >RIV/00179906:_____/17:10367303 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.radonc.2017.02.017" target="_blank" >http://dx.doi.org/10.1016/j.radonc.2017.02.017</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.radonc.2017.02.017" target="_blank" >10.1016/j.radonc.2017.02.017</a>

Result language

angličtina

Original language name

Feasibility of atlas-based active bone marrow sparing intensity modulated radiation therapy for cervical cancer

Original language description

Background: To test the hypothesis that atlas-based active bone marrow (ABM) -sparing intensity modulated radiation therapy (IMRT) yields similar dosimetric results compared to custom ABM-sparing IMRT for cervical cancer patients. Methods: We sampled 62 cervical cancer patients with pre-treatment FDG-PET/CT in training (n = 32) or test (n = 30) sets. ABM was defined as the subvolume of the pelvic bone marrow (PBM) with standardized uptake value (SUV) above the mean on the average FDG-PET image (ABM(Atlas)) vs the individual&apos;s PET (ABM(custom)). Both were deformed to the planning CI&apos;. Overlap between the two subvolumes was measured using the Dice coefficient. Three IMRT plans designed to spare PBM, ABM(Atlas), or ABM(custom) were compared for 30 test patients. Dosimetric parameters were used to evaluate plan quality. Results: ABM(Atlas) and ABM(custom) volumes were not significantly different (p = 0.90), with a mean Dice coefficient of 0.75, indicating good agreement. Compared to IMRT plans designed to spare PBM and ABM(custom), ABM(Atlas)-Sparing IMRT plans achieved excellent target coverage and normal tissue sparing, without reducing dose to ABMcustom, (mean ABM(custom) dose 29.4 Gy vs. 27.1 Gy vs. 26.9 Gy, respectively; p = 0.10); however, PTV coverage and bowel sparing were slightly reduced. Conclusions: Atlas-based ABM sparing IMRT is clinically feasible and may obviate the need for customized ABM-sparing as a strategy to reduce hematologic toxicity.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Radiotherapy and Oncology

ISSN

0167-8140

e-ISSN

—

Volume of the periodical

123

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

325-330

UT code for WoS article

000403028800025

EID of the result in the Scopus database

2-s2.0-85019613782