Parathyroid hormone - reference values and association with other bone metabolism markers in very low birth weight infants - pilot study
Result description
Purpose: The aim of this pilot study was to estimate physiological parathyroid hormone (PTH) levels and their relationship with bone metabolism parameters in otherwise healthy preterm newborns with birth weight 1000-1500 g. Methods: PTH, 25(OH)D, S-Ca, S-P, and ALP were analysed from blood samples obtained from 20 preterm infants once a week up to the 36th gestational week. Results: Of the total 134 examined serum samples for PTH levels, the estimated range was 1.6-9.3pmol/l (15.1-87.7 pg/ml). No statistically significant correlation of PTH level with that of S-Ca, S-P, or ALP was observed, except for the 56th day of life (p=.03; Rho= 0.76; n=8). From the second month of life, there was a statistically significant relationship only between PTH and 25(OH)D (Rho=-0.71, p .0001). In our cohort, vitamin D deficiency (20 ng/ml) occurred in 75% at birth and at 30% in the 36th gestational week. Conclusions: The physiological range indicated by the measurements was close to the reference limits for adults (1-7 pmol/l; 9.4-66 pg/ml). PTH level above this range can be considered as hyperparathyroidism in preterm neonates.
Keywords
vitamin Dpreterm newbornparathyroid hormoneMetabolic bone disease
The result's identifiers
Result code in IS VaVaI
Alternative codes found
RIV/00216208:11150/19:10383362
Result on the web
https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=kwrpkDSOor
DOI - Digital Object Identifier
Alternative languages
Result language
angličtina
Original language name
Parathyroid hormone - reference values and association with other bone metabolism markers in very low birth weight infants - pilot study
Original language description
Purpose: The aim of this pilot study was to estimate physiological parathyroid hormone (PTH) levels and their relationship with bone metabolism parameters in otherwise healthy preterm newborns with birth weight 1000-1500 g. Methods: PTH, 25(OH)D, S-Ca, S-P, and ALP were analysed from blood samples obtained from 20 preterm infants once a week up to the 36th gestational week. Results: Of the total 134 examined serum samples for PTH levels, the estimated range was 1.6-9.3pmol/l (15.1-87.7 pg/ml). No statistically significant correlation of PTH level with that of S-Ca, S-P, or ALP was observed, except for the 56th day of life (p=.03; Rho= 0.76; n=8). From the second month of life, there was a statistically significant relationship only between PTH and 25(OH)D (Rho=-0.71, p .0001). In our cohort, vitamin D deficiency (20 ng/ml) occurred in 75% at birth and at 30% in the 36th gestational week. Conclusions: The physiological range indicated by the measurements was close to the reference limits for adults (1-7 pmol/l; 9.4-66 pg/ml). PTH level above this range can be considered as hyperparathyroidism in preterm neonates.
Czech name
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Czech description
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Classification
Type
Jimp - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of Maternal-Fetal & Neonatal Medicine
ISSN
1476-7058
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
17
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
2860-2867
UT code for WoS article
000476596900012
EID of the result in the Scopus database
2-s2.0-85044306673
Result type
Jimp - Article in a specialist periodical, which is included in the Web of Science database
OECD FORD
Paediatrics
Year of implementation
2019