Detailed Mapping of Methylcytosine Positions at the CpG Island Surrouding the Pa Promoter at the bcr-abl Locus in CML Patients and Two Cell Lines, K562 and BV173.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209627%3A_____%2F00%3A00000023" target="_blank" >RIV/00209627:_____/00:00000023 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Detailed Mapping of Methylcytosine Positions at the CpG Island Surrouding the Pa Promoter at the bcr-abl Locus in CML Patients and Two Cell Lines, K562 and BV173.

Original language description

In most CML cases, one of two abl promoters (Pa) is nested within the bcr-abl transcription unit, but appears to be silent. Recently de novo methylation of the Pa region and its correlation with disease progression were reported. As these previous studies were limited to the use of metylation-sensitive restriction endonucleases, our aim here was to obtain a cpmplete map of methylcytosines and its variants in CML patients in model cell lines.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood Cells, Molecules, and Diseases

ISSN

1079-9796

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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