Decreased exercise capacity and sleep-desordered breathing in patient with hyperthrophic cardiomyopathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209775%3A_____%2F15%3A%230000319" target="_blank" >RIV/00209775:_____/15:#0000319 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1378/chest.14-1498" target="_blank" >http://dx.doi.org/10.1378/chest.14-1498</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1378/chest.14-1498" target="_blank" >10.1378/chest.14-1498</a>

Result language

angličtina

Original language name

Decreased exercise capacity and sleep-desordered breathing in patient with hyperthrophic cardiomyopathy

Original language description

Mechanisms of decreased exercise capacity in patients with hypertrophic cardiomyopathy (HCM) are not well understood. Sleep-disordered breathing (SDB) is a highly prevalent but treatable disorder in patients with HCM. The role of comorbid SBD in the attenuated exercise capacity in HCM has not been previously. Overnight oximetry, cardiopulmonary exercise testing, and echocardiographic studies were performed in consecutive patients with HCM seen at the Mayo Clinic. SDB was considered present if the oxygen desaturation index (number of <= 4% desaturations/h) was >= 10. Peak oxygen consumption (V O2 peak) (the most reproducible and prognostic measure of cardiovascular fitness) was then correlated with the presence and severity of SBD. A total of 198 patients with HCM were studied (age 53+-16 years; 122 men), of whom 32% met the criteria for the SBD diagnosis. Patients with SBD had decreased V 02 peak compared with those without SBD (16 mL O2/kg/min vs 21 mL O2/kg/min, P < 0.001). SBD remained significantly associated with V O2peak after accounting for confounding clinical variables (P < 0.001) including age, sex, BMI, atrial fibrillation, and coronary artery disease. In patients with HCM, the presence of SBD is associated with decreased V O2 peak. SBD may represent an important and potentially modifiable contributor to impaired exercise tolerance in this unique population.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chest

ISSN

0012-3692

e-ISSN

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Volume of the periodical

147

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

1574-1581

UT code for WoS article

000355837900038

EID of the result in the Scopus database

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