Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F03%3A00008006" target="_blank" >RIV/00209805:_____/03:00008006 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/03:00008209
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients
Original language description
Using immunoprecipitation and Western blots performed on lysates made of melanoma cells derived from patients with clinical stage II/III and employing specific anti-STAT 1 PS 727/PY 701 immunoprobes, we show that STAT 1 activation response induced by IFN-alfa/-gamma is significantly impaired. In average, three quarters of patients were lacking phosphorylation at S 727. STAT 1 PY 701 was not inducible by IFN-alfa in 63% and by IFN-gamma in 34% of samples However, these STAT 1 activation defects showed nocorrelation with the disease outcome and immunotherapy response as indicated by progression-free survival profiles in patients treated with IFN-alfa2b.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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