Protein quality control and cancerogenesis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000301" target="_blank" >RIV/00209805:_____/12:#0000301 - isvavai.cz</a>

Result on the web

<a href="http://www.linkos.cz/files/klinicka-onkologie/174/4125.pdf" target="_blank" >http://www.linkos.cz/files/klinicka-onkologie/174/4125.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Protein quality control and cancerogenesis

Original language description

Both nascent and mature proteins are prone to damaging changes induced by either external or internal stimuli. Dysfunctional or misfolded proteins cause direct physiological risk in crowded cellular environment and must be readily and efficiently eliminated. To ensure protein homeostasis, eukaryotic cells have evolved several protein quality control machineries. Protein quality control plays a special role in cancer cells. Genetic instability causing increased production of damaged and/or deregulated proteins is a hallmark of cancer cells. Therefore, intrinsic genetic instability together with hostile tumour microenvironment represents a demanding task for protein quality control machineries in tumours. Regulation of general protein turnover as well asdegradation of tumour-promoting/suppressing proteins by protein quality control machineries thus represent an important processes involved in cancer development and progression. The review focuses on the description of three major protei

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Klinická onkologie

ISSN

0862-495X

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

supplementum 2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

"2S38"-"2S44"

UT code for WoS article

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EID of the result in the Scopus database

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