The causes and consequences of genetic heterogeneity in cancer evolution

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33145701" target="_blank" >RIV/61989592:15110/13:33145701 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/nature12625" target="_blank" >http://dx.doi.org/10.1038/nature12625</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/nature12625" target="_blank" >10.1038/nature12625</a>

Result language
angličtina
Original language name
The causes and consequences of genetic heterogeneity in cancer evolution
Original language description
Recent studies have revealed extensive genetic diversity both between and within tumours. This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a significant challenge to personalized cancer medicine. A major cause of genetic heterogeneity in cancer is genomic instability. This instability leads to an increased mutation rate and can shape the evolution of the cancer genome through a plethora of mechanisms. By understanding these mechanisms we can gain insight into the common pathways of tumour evolution that could support the development of future therapeutic strategies.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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