Identification and characterisation of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000306" target="_blank" >RIV/00209805:_____/12:#0000306 - isvavai.cz</a>

Result on the web

<a href="http://www.linkos.cz/files/klinicka-onkologie/174/4135.pdf" target="_blank" >http://www.linkos.cz/files/klinicka-onkologie/174/4135.pdf</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Identification and characterisation of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies

Original language description

Background: Cancer metastasis involves changes in signalling pathways, cell adhesion, migration and invasiveness. Modern proteomic, mass spectrometry based techniques enable discovery of new pro-metastatic proteins and their functional partners. Also, they might be involved in their functional characterisation and validation towards development of new diagnostic and therapeutic approaches. Aim: The aim of this communication is to describe current possibilities for proteomic techniques in the discovery and characterisation of pro-metastatic targets. The NF-?B pathway is one of the players responsible for a number of pro-metastatic processes. The related proteins can be discovered using untargeted proteomic approaches by comparing proteomes with different metastatic potential. Stable isotope labelling based methods enable a parallel analysis of more tumour samples. The identified pro-metastatic proteins can be characterised in relationship to cell migration, invasiveness and proliferatio

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Klinická onkologie

ISSN

0862-495X

e-ISSN

—

Volume of the periodical

25

Issue of the periodical within the volume

supplementum 2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

"2S70"-"2S77"

UT code for WoS article

—

EID of the result in the Scopus database

—