Identification and characterization of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00058654" target="_blank" >RIV/00216224:14310/12:00058654 - isvavai.cz</a>

Result on the web

<a href="http://www.linkos.cz/casopis-klinicka-onkologie/hledani-clanku/skupina/a/zobrazit/ids/4135/" target="_blank" >http://www.linkos.cz/casopis-klinicka-onkologie/hledani-clanku/skupina/a/zobrazit/ids/4135/</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Identification and characterization of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies

Original language description

Background: Cancer metastasis involves changes in signalling pathways, cell adhesion, migration and invasiveness. Modern proteomic, mass spectrometry based techniques enable discovery of new pro-metastatic proteins and their functional partners. Also, they might be involved in their functional characterization and validation towards development of new diagnostic and therapeutic approaches. Aim: The aim of this communication is to describe current possibilities for proteomic techniques in the discovery and characterization of pro-metastatic targets. The NF-kappaB pathway is one of the players responsible for a number of pro-metastatic processes. The related proteins can be discovered using untargeted proteomic approaches by comparing proteomes with different metastatic potential. Stable isotope labelling based methods enable a parallel analysis of more tumour samples.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GAP304%2F10%2F0868" target="_blank" >GAP304/10/0868: The proteomics-based study on molecular mechanisms of early lymph node metastases formation in low-grade breast cancer</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Klinická onkologie

ISSN

0862-495X

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

Suppl. 2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

"2S70"-"2S77"

UT code for WoS article

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EID of the result in the Scopus database

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