Tumor hypoxia and its clinical significance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F13%3A%230000445" target="_blank" >RIV/00209805:_____/13:#0000445 - isvavai.cz</a>

Result on the web

<a href="http://www.mzm.cz/fileadmin/user_upload/publikace/casopisy/fm_49_2_2013/fm-2-2013-abstract-08.pdf" target="_blank" >http://www.mzm.cz/fileadmin/user_upload/publikace/casopisy/fm_49_2_2013/fm-2-2013-abstract-08.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Tumor hypoxia and its clinical significance

Original language description

In the light of intense cancer research, the tumor microenvironment has become a matter of great interest as it can influence many different aspects of tumor progression including growth, metastatic potential and response to treatment. In that field, lowoxygen pressure (hypoxia), which evolves from uncontrollable growth and poor vasculature, plays a significant role. The main executer of tumor cell responses to hypoxia is a transcription factor HIF-1 (hypoxia-inducible factor 1), which triggers molecular adjustments helping cells to overcome those unfavorable conditions. It is also known that hypoxia renders cells resistant to treatment and in consequence affects patient outcome. This review focuses on HIF-1-dependent adaptations to insufficient oxygen delivery as well as describing clinical problems arising from hypoxia. Lastly, it highlights importance of targeted therapy aiming at hypoxic pathways.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Mendeliana

ISSN

0085-0748

e-ISSN

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Volume of the periodical

49

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

69-73

UT code for WoS article

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EID of the result in the Scopus database

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