Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10296413" target="_blank" >RIV/00216208:11130/15:10296413 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/15:10296413

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2015.025" target="_blank" >http://dx.doi.org/10.5507/bp.2015.025</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2015.025" target="_blank" >10.5507/bp.2015.025</a>

Result language

angličtina

Original language name

Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1

Original language description

Background. The aim of this review is to provide the information about molecular basis of hypoxia-induced chemoresistance, focusing on the possibility of diagnostic and therapeutic use. Results. Hypoxia is a common feature of tumors and represents an independent prognostic factor in many cancers. It is the result of imbalances in the intake and consumption of oxygen caused by abnormal vessels in the tumor and the rapid proliferation of cancer cells. Hypoxia-induced resistance to cisplatin, doxorubicin,etoposide, melphalan, 5-flouoruracil, gemcitabine, and docetaxel has been reported in a number of experiments. Adaptation of tumor cells to hypoxia has important biological effects. The most studied factor responsible for these effects is hypoxia-inducible factor-1 (HIF-1) that significantly contributes to the aggressiveness and chemoresistance of different tumors. The HIF-1 complex, induced by hypoxia, binds to target genes, thereby increasing the expression of many genes. In addition,

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

—

Volume of the periodical

159

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

12

Pages from-to

166-177

UT code for WoS article

000359128900001

EID of the result in the Scopus database

2-s2.0-84934274884