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MicroRNAs involved in chemo- and radioresistance of high-grade glioma

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F13%3A%230000466" target="_blank" >RIV/00209805:_____/13:#0000466 - isvavai.cz</a>

  • Result on the web

    <a href="http://link.springer.com/article/10.1007%2Fs13277-013-0772-5" target="_blank" >http://link.springer.com/article/10.1007%2Fs13277-013-0772-5</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s13277-013-0772-5" target="_blank" >10.1007/s13277-013-0772-5</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    MicroRNAs involved in chemo- and radioresistance of high-grade glioma

  • Original language description

    High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. Therefore, they present promising biomarkers and therapeutic targets that might overcome the resistance to treatm

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT11214" target="_blank" >NT11214: Identification and functional characterization of microRNAs with predictive significance in patients with glioblastoma</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Tumor Biology

  • ISSN

    1010-4283

  • e-ISSN

  • Volume of the periodical

    34

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    20

  • Pages from-to

    1969-1978

  • UT code for WoS article

    000321912500001

  • EID of the result in the Scopus database