MicroRNAs involved in chemo- and radioresistance of high-grade gliomas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F13%3A%230002197" target="_blank" >RIV/65269705:_____/13:#0002197 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/13:00065588
Result on the web
<a href="http://dx.doi.org/10.1007/s13277-013-0772-5" target="_blank" >http://dx.doi.org/10.1007/s13277-013-0772-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13277-013-0772-5" target="_blank" >10.1007/s13277-013-0772-5</a>
Alternative languages
Result language
angličtina
Original language name
MicroRNAs involved in chemo- and radioresistance of high-grade gliomas
Original language description
High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. Therefore, they present promising biomarkers and therapeutic targets that might overcome the resistance to treatm
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Tumor Biology
ISSN
1010-4283
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
4
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
1969-1978
UT code for WoS article
000321912500001
EID of the result in the Scopus database
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