HDMX folds the nascent p53 mRNA following activation by the ATM kinase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F14%3A%230000519" target="_blank" >RIV/00209805:_____/14:#0000519 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.molcel.2014.02.035" target="_blank" >http://dx.doi.org/10.1016/j.molcel.2014.02.035</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molcel.2014.02.035" target="_blank" >10.1016/j.molcel.2014.02.035</a>
Alternative languages
Result language
angličtina
Original language name
HDMX folds the nascent p53 mRNA following activation by the ATM kinase
Original language description
In addition to its anticancer function, p53 (regulated by MDM2) has recently been shown to control intracellular metabolic processes. It participates in the regulation of glucose, fatty and amino acid and purine metabolism, influences mitochondrial integrity and oxidative phosphorylation, insulin sensitivity, antioxidant response and autophagy. With respect to the possible impact of genetic variability in p53 and MDM2 on metabolic compensation the aim of the study was to analyse the effect of common germ line Single Nucleotide Polymorphisms (SNPs) - Arg72Pro in the TP53 and SNP309 in the MDM2 - on the progression of Diabetic Nephropathy (DN), cardiovascular morbidity and mortality and all-cause mortality in Type 2 Diabetes Mellitus (T2DM) subjects. Thecross-sectional study comprised a total of 309 (a sum of 155 and 154) unrelated Caucasian diabetic patients with diabetes duration at least 10 years and variable renal function at baseline (309, mean age was 67.2 ? 10.8 years). The stage
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular cell
ISSN
1097-2765
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
500-511
UT code for WoS article
000336026900016
EID of the result in the Scopus database
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