Association of the Arg72Pro Polymorphism in p53 with Progression of Diabetic Nephropathy in T2DM Subjects
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00075467" target="_blank" >RIV/00216224:14110/14:00075467 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/14:#0000518
Result on the web
<a href="http://dx.doi.org/10.4172/2161-0959.1000153" target="_blank" >http://dx.doi.org/10.4172/2161-0959.1000153</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4172/2161-0959.1000153" target="_blank" >10.4172/2161-0959.1000153</a>
Alternative languages
Result language
angličtina
Original language name
Association of the Arg72Pro Polymorphism in p53 with Progression of Diabetic Nephropathy in T2DM Subjects
Original language description
Objective: In addition to its anticancer function, p53 (regulated by murine double minute 2 oncoprotein, MDM2) has recently been shown to control intracellular metabolic processes. It participates in the regulation of glucose, fatty and amino acid and purine metabolism, influences mitochondrial integrity and oxidative phosphorylation, insulin sensitivity, antioxidant response and autophagy. With respect to the possible impact of genetic variability in p53 and MDM2 on metabolic compensation the aim of the study was to analyse the effect of common germ line Single Nucleotide Polymorphisms (SNPs) - Arg72Pro in the TP53 and SNP309 in the MDM2 - on the progression of Diabetic Nephropathy (DN), cardiovascular morbidity and mortality and all-cause mortality in Type 2 Diabetes Mellitus (T2DM) subjects.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Nephrology & Therapeutics
ISSN
2161-0959
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
1-3
UT code for WoS article
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EID of the result in the Scopus database
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