The role of AGR2 and AGR3 in cancer: similar but not identical

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A%230000605" target="_blank" >RIV/00209805:_____/15:#0000605 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejcb.2015.01.002" target="_blank" >http://dx.doi.org/10.1016/j.ejcb.2015.01.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejcb.2015.01.002" target="_blank" >10.1016/j.ejcb.2015.01.002</a>

Result language
angličtina
Original language name
The role of AGR2 and AGR3 in cancer: similar but not identical
Original language description
In the past decades, highly related members of the protein disulphide isomerase family, anterior gradient protein AGR2 and AGR3, attracted researchers? attention due to their putative involvement in developmental processes and carcinogenesis. While AGR2has been widely demonstrated as a metastasis-related protein whose elevated expression predicts worse patient outcome, little is known about AGR3?s role in tumour biology. Thus, we aim to confront the issue of AGR3 function in physiology and pathology inthe following review by comparing this protein with the better-described homologue AGR2. Relying on available data and in silico analyses, we show that AGR proteins are co-expressed or uncoupled in context-dependent manners in diverse carcinomas and healthy tissues. Further, we discuss plausible roles of both proteins in tumour-associated processes such as differentiation, proliferation, migration, invasion and metastasis. This work brings new hints and stimulates further thoughts on hi
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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