The diverse oncogenic and tumour suppressor roles of p63 and p73 in cancer: a review by cancer site
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A%230000606" target="_blank" >RIV/00209805:_____/15:#0000606 - isvavai.cz</a>
Result on the web
<a href="http://www.hh.um.es/Abstracts/Vol_30/30_5/30_5_503.htm" target="_blank" >http://www.hh.um.es/Abstracts/Vol_30/30_5/30_5_503.htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14670/HH-30.503" target="_blank" >10.14670/HH-30.503</a>
Alternative languages
Result language
angličtina
Original language name
The diverse oncogenic and tumour suppressor roles of p63 and p73 in cancer: a review by cancer site
Original language description
p63 and p73, the two other members of the p53 family, were identified almost 15 years ago. Here, we review their potential use for diagnosis, prognosis and prediction of response to therapy in various cancers. The two genes show distinct expression patterns in both normal and cancer tissues and each gene gives rise to multiple protein isoforms with different activities, including those with tumour-suppressor or oncogenic effects. Despite such complexity, some common themes emerge; p63 is commonly overexpressed as the ?Np63 isoform and sometimes associated with TP63 amplification, whereas p73 is often reduced (by methylation or gene loss), or there is an increase in the ratio of ?Np73 to TAp73. These generalisations do not apply universally; TAp63 is overexpressed in haematological malignancies, TP63 mis-sense mutations have been reported in squamous cancers and TP63 translocations occur in lymphomas and some lung adenocarcinomas. There are associations with disease prognosis and respon
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Histology and histopathology
ISSN
0213-3911
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
5
Country of publishing house
ES - SPAIN
Number of pages
19
Pages from-to
503-521
UT code for WoS article
000352500300001
EID of the result in the Scopus database
2-s2.0-84929762237