Intrinsic Electrocatalysis in DNA
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00077987" target="_blank" >RIV/00209805:_____/18:00077987 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/18:00506881
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/celc.201700888" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/celc.201700888</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/celc.201700888" target="_blank" >10.1002/celc.201700888</a>
Alternative languages
Result language
angličtina
Original language name
Intrinsic Electrocatalysis in DNA
Original language description
We show, for the first time, that DNA produces an electrocatalytic square wave voltammetric reduction peak or chronopotentiometric peak HDNA at mercury and solid amalgam electrodes. These peaks are attributed to the catalytic hydrogen evolution reaction, allowing label-free detection of chromosomal DNA and oligodeoxynucleotides (ODNs) below parts per million and nanomolar levels, respectively. By using peak HDNA at high current densities, native chromosomal DNA was distinguished from its denatured form. With this method, damage of DNA from human cancer cells by ionizing radiation or sonication was detected. Sensitivity of the DNA determination was greatly enhanced in the presence of [Co(NH3)6]3+. Chromosomal DNA and ODNs can be detected at concentrations 2-3 orders lower than any earlier voltammetric or chronopotentiometric label-free methods. In the presence of 4 mM [Co(NH3)6]3+, DNA from human cancer cells was easily detected at 5 ng/mL, that is, below the concentration level of cell-free DNA in body fluids.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemElectroChem
ISSN
2196-0216
e-ISSN
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Volume of the periodical
5
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
936-942
UT code for WoS article
000428374400014
EID of the result in the Scopus database
2-s2.0-85034867442