All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Intrinsic Electrocatalysis in DNA

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00077987" target="_blank" >RIV/00209805:_____/18:00077987 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081707:_____/18:00506881

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/celc.201700888" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/celc.201700888</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/celc.201700888" target="_blank" >10.1002/celc.201700888</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Intrinsic Electrocatalysis in DNA

  • Original language description

    We show, for the first time, that DNA produces an electrocatalytic square wave voltammetric reduction peak or chronopotentiometric peak HDNA at mercury and solid amalgam electrodes. These peaks are attributed to the catalytic hydrogen evolution reaction, allowing label-free detection of chromosomal DNA and oligodeoxynucleotides (ODNs) below parts per million and nanomolar levels, respectively. By using peak HDNA at high current densities, native chromosomal DNA was distinguished from its denatured form. With this method, damage of DNA from human cancer cells by ionizing radiation or sonication was detected. Sensitivity of the DNA determination was greatly enhanced in the presence of [Co(NH3)6]3+. Chromosomal DNA and ODNs can be detected at concentrations 2-3 orders lower than any earlier voltammetric or chronopotentiometric label-free methods. In the presence of 4 mM [Co(NH3)6]3+, DNA from human cancer cells was easily detected at 5 ng/mL, that is, below the concentration level of cell-free DNA in body fluids.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    ChemElectroChem

  • ISSN

    2196-0216

  • e-ISSN

  • Volume of the periodical

    5

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    8

  • Pages from-to

    936-942

  • UT code for WoS article

    000428374400014

  • EID of the result in the Scopus database

    2-s2.0-85034867442