ColPortal, an integrative multiomic platform for analysing epigenetic interactions in colorectal cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F19%3A00078345" target="_blank" >RIV/00209805:_____/19:00078345 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/19:00112508
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823353/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823353/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41597-019-0198-z" target="_blank" >10.1038/s41597-019-0198-z</a>
Alternative languages
Result language
angličtina
Original language name
ColPortal, an integrative multiomic platform for analysing epigenetic interactions in colorectal cancer
Original language description
Colorectal cancer (CRC) is the third leading cause of cancer mortality worldwide. Different pathological pathways and molecular drivers have been described and some of the associated markers are used to select effective anti-neoplastic therapy. More recent evidence points to a causal role of microbiota and altered microRNA expression in CRC carcinogenesis, but their relationship with pathological drivers or molecular phenotypes is not clearly established. Joint analysis of clinical and omics data can help clarify such relations. We present ColPortal, a platform that integrates transcriptomic, microtranscriptomic, methylomic and microbiota data of patients with colorectal cancer. ColPortal also includes detailed information of histological features and digital histological slides from the study cases, since histology is a morphological manifestation of a complex molecular change. The current cohort consists of Caucasian patients from Europe. For each patient, demographic information, location, histology, tumor staging, tissue prognostic factors, molecular biomarker status and clinical outcomes are integrated with omics data. ColPortal allows one to perform multiomics analyses for groups of patients selected by their clinical data.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific data
ISSN
2052-4463
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
255
UT code for WoS article
000494480700001
EID of the result in the Scopus database
2-s2.0-85074370857