Molecular Links between Central Obesity and Breast Cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F19%3A00078346" target="_blank" >RIV/00209805:_____/19:00078346 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/19:00112968
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862548/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862548/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms20215364" target="_blank" >10.3390/ijms20215364</a>
Alternative languages
Result language
angličtina
Original language name
Molecular Links between Central Obesity and Breast Cancer
Original language description
Worldwide, breast cancer (BC) is the most common malignancy in women, in regard to incidence and mortality. In recent years, the negative role of obesity during BC development and progression has been made abundantly clear in several studies. However, the distribution of body fat may be more important to analyze than the overall body weight. In our review of literature, we reported some key findings regarding the role of obesity in BC development, but focused more on central adiposity. Firstly, the adipose microenvironment in obese people bears many similarities with the tumor microenvironment, in respect to associated cellular composition, chronic low-grade inflammation, and high ratio of reactive oxygen species to antioxidants. Secondly, the adipose tissue functions as an endocrine organ, which in obese people produces a high level of tumor-promoting hormones, such as leptin and estrogen, and a low level of the tumor suppressor hormone, adiponectin. As follows, in BC this leads to the activation of oncogenic signaling pathways: NF kappa B, JAK, STAT3, AKT. Moreover, overall obesity, but especially central obesity, promotes a systemic and local low grade chronic inflammation that further stimulates the increase of tumor-promoting oxidative stress. Lastly, there is a constant exchange of information between BC cells and adipocytes, mediated especially by extracellular vesicles, and which changes the transcription profile of both cell types to an oncogenic one with the help of regulatory non-coding RNAs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International journal of molecular sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
21
Country of publishing house
CH - SWITZERLAND
Number of pages
21
Pages from-to
"pii: E5364"
UT code for WoS article
000498946100122
EID of the result in the Scopus database
2-s2.0-85074266755