The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00396406" target="_blank" >RIV/60077344:_____/13:00396406 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1160/TH12-09-0703" target="_blank" >http://dx.doi.org/10.1160/TH12-09-0703</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1160/TH12-09-0703" target="_blank" >10.1160/TH12-09-0703</a>

Result language

angličtina

Original language name

The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance

Original language description

Obesity is characterised by a chronic state of low-grade inflammation in different tissues including the vasculature. There is a causal link between adipose tissue (AT) inflammation and obesity-related metabolic complications, such as the development ofinsulin resistance and subsequently of type 2 diabetes. Intense efforts in the recent years have aimed at dissecting the pathophysiology of AT inflammation. The role of both innate and adaptive immune cells, such as macrophages or cytotoxic T cells in ATinflammation has been demonstrated. Besides these cells, more leukocyte subpopulations have been recently implicated in obesity, including neutrophils and eosinophils, mast cells, natural killer cells or dendritic cells. The involvement of multiple leukocyte subpopulations underlines the complexity of obesity-associated AT inflammation. In this review, we discuss the role of innate immune cells in AT inflammation, obesity and related metabolic disorders.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Thrombosis and Haemostasis

ISSN

0340-6245

e-ISSN

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Volume of the periodical

109

Issue of the periodical within the volume

3

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

399-406

UT code for WoS article

000316164200007

EID of the result in the Scopus database

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