Obesity-Induced Changes in Bone Marrow Homeostasis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00531064" target="_blank" >RIV/67985823:_____/20:00531064 - isvavai.cz</a>

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fendo.2020.00294/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fendo.2020.00294/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fendo.2020.00294" target="_blank" >10.3389/fendo.2020.00294</a>

Result language

angličtina

Original language name

Obesity-Induced Changes in Bone Marrow Homeostasis

Original language description

Obesity is characterized by low-grade inflammation, which is accompanied by increased accumulation of immune cells in peripheral tissues including adipose tissue (AT), skeletal muscle, liver and pancreas, thereby impairing their primary metabolic functions in the regulation of glucose homeostasis. Obesity has also shown to have a detrimental effect on bone homeostasis by altering bone marrow and hematopoietic stem cell differentiation and thus impairing bone integrity and immune cell properties. The origin of immune cells arises in the bone marrow, which has been shown to be affected with the obesogenic condition via increased cellularity and shifting differentiation and function of hematopoietic and bone marrow mesenchymal stem cells in favor of myeloid progenitors and increased bone marrow adiposity. These obesity-induced changes in the bone marrow microenvironment lead to dramatic bone marrow remodeling and compromising immune cell functions, which in turn affect systemic inflammatory conditions and regulation of whole-body metabolism. However, there is limited information on the inflammatory secretory factors creating the bone marrow microenvironment and how these factors changed during metabolic complications. This review summarizes recent findings on inflammatory and cellular changes in the bone marrow in relation to obesity and further discuss whether dietary intervention or physical activity may have beneficial effects on the bone marrow microenvironment and whole-body metabolism.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10601 - Cell biology

Project

<a href="/en/project/GA20-03586S" target="_blank" >GA20-03586S: Bone marrow adipose tissue (BMAT) as a novel adipose depot in the regulation of the whole body metabolism and bone homeostasis.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Endocrinology

ISSN

1664-2392

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

May 12

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

294

UT code for WoS article

000537214700001

EID of the result in the Scopus database

2-s2.0-85086522610