Occupational exposure to ionizing radiation and risk of lymphoma subtypes: results of the Epilymph European case-control study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F20%3A00078388" target="_blank" >RIV/00209805:_____/20:00078388 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/20:00124640
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183712/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183712/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12940-020-00596-9" target="_blank" >10.1186/s12940-020-00596-9</a>
Alternative languages
Result language
angličtina
Original language name
Occupational exposure to ionizing radiation and risk of lymphoma subtypes: results of the Epilymph European case-control study
Original language description
Evidence linking risk of lymphoma and B-cell lymphoma subtypes to ionizing radiation is inconclusive, particularly at low exposure levels. METHODS: We investigated risk of lymphoma (all subtypes), B-cell lymphomas, and its major subtypes, associated with low-level occupational exposure to ionizing radiation, in 2346 lymphoma cases and 2463 controls, who participated in the multicenter EpiLymph case-control study. We developed a job-exposure matrix to estimate exposure to ionizing radiation, distinguishing between internal and external radiation, and we applied it to the lifetime occupational history of study subjects, We calculated the Odds Ratio (OR) and its 95% confidence interval (95% CI) for lymphoma (all subtypes combined), B-cell lymphoma, and its major subtypes using unconditional, polytomous logistic regression adjusting for age, gender, and education. RESULTS: We did not observe an association between exposure metrics of external and internal radiation and risk of lymphoma (all subtypes), nor with B-cell lymphoma, or its major subtypes, at the levels regularly experienced in occupational settings. An elevated risk of diffuse large B cell lymphoma was observed among the most likely exposed study subjects with relatively higher exposure intensity, which would be worth further investigation. CONCLUSIONS: Further investigation is warranted on risk of B cell lymphoma subtypes associated with low-level occupational exposure to external ionizing radiation, and to clarify whether lymphoma should be included among the cancer outcomes related to ionizing radiation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental health
ISSN
1476-069X
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
43
UT code for WoS article
000529993200001
EID of the result in the Scopus database
2-s2.0-85084030609