Occupational exposure to ionizing radiation and risk of lymphoma subtypes: results of the Epilymph European case-control study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00124640" target="_blank" >RIV/00216224:14110/20:00124640 - isvavai.cz</a>

Alternative codes found

RIV/00209805:_____/20:00078388

Result on the web

<a href="https://ehjournal.biomedcentral.com/articles/10.1186/s12940-020-00596-9" target="_blank" >https://ehjournal.biomedcentral.com/articles/10.1186/s12940-020-00596-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12940-020-00596-9" target="_blank" >10.1186/s12940-020-00596-9</a>

Result language

angličtina

Original language name

Occupational exposure to ionizing radiation and risk of lymphoma subtypes: results of the Epilymph European case-control study

Original language description

Background Evidence linking risk of lymphoma and B-cell lymphoma subtypes to ionizing radiation is inconclusive, particularly at low exposure levels. Methods We investigated risk of lymphoma (all subtypes), B-cell lymphomas, and its major subtypes, associated with low-level occupational exposure to ionizing radiation, in 2346 lymphoma cases and 2463 controls, who participated in the multicenter EpiLymph case-control study. We developed a job-exposure matrix to estimate exposure to ionizing radiation, distinguishing between internal and external radiation, and we applied it to the lifetime occupational history of study subjects, We calculated the Odds Ratio (OR) and its 95% confidence interval (95% CI) for lymphoma (all subtypes combined), B-cell lymphoma, and its major subtypes using unconditional, polytomous logistic regression adjusting for age, gender, and education. Results We did not observe an association between exposure metrics of external and internal radiation and risk of lymphoma (all subtypes), nor with B-cell lymphoma, or its major subtypes, at the levels regularly experienced in occupational settings. An elevated risk of diffuse large B cell lymphoma was observed among the most likely exposed study subjects with relatively higher exposure intensity, which would be worth further investigation. Conclusions Further investigation is warranted on risk of B cell lymphoma subtypes associated with low-level occupational exposure to external ionizing radiation, and to clarify whether lymphoma should be included among the cancer outcomes related to ionizing radiation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental health

ISSN

1476-069X

e-ISSN

1476-069X

Volume of the periodical

19

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1-11

UT code for WoS article

000529993200001

EID of the result in the Scopus database

2-s2.0-85084030609