How Different Are the Molecular Mechanisms of Nodal and Distant Metastasis in Luminal A Breast Cancer?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F20%3A00078459" target="_blank" >RIV/00209805:_____/20:00078459 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/20:00118621

Result on the web

<a href="https://pubmed.ncbi.nlm.nih.gov/32947901/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/32947901/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers12092638" target="_blank" >10.3390/cancers12092638</a>

Result language

angličtina

Original language name

How Different Are the Molecular Mechanisms of Nodal and Distant Metastasis in Luminal A Breast Cancer?

Original language description

Lymph node status is one of the best prognostic factors in breast cancer, however, its association with distant metastasis is not straightforward. Here we compare molecular mechanisms of nodal and distant metastasis in molecular subtypes of breast cancer, with major focus on luminal A patients. We analyze a new cohort of 706 patients (MMCI_706) as well as an independent cohort of 836 primary tumors with full gene expression information (SUPERTAM_HGU133A). We evaluate the risk of distant metastasis, analyze targetable molecular mechanisms in Gene Set Enrichment Analysis and identify relevant inhibitors. Lymph node positivity is generally associated with NF-κB and Src pathways and is related to high risk (OR: 5.062 and 2.401 in MMCI_706 and SUPERTAM_HGU133A, respectively, p &lt; 0.05) of distant metastasis in luminal A patients. However, a part (LESS-THAN OR EQUAL TO15%) of lymph node negative tumors at the diagnosis develop the distant metastasis which is related to cell proliferation control and thrombolysis. Distant metastasis of lymph node positive patients is mostly associated with immune response. These pro-metastatic mechanisms further vary in other molecular subtypes. Our data indicate that the management of breast cancer and prevention of distant metastasis requires stratified approach based on targeted strategies.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/NV19-08-00250" target="_blank" >NV19-08-00250: Proteotype classification of renal cell carcinoma for prognosis and therapy response</a><br>

Continuities

—

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancers

ISSN

2072-6694

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

9

Country of publishing house

CH - SWITZERLAND

Number of pages

26

Pages from-to

"E2638"

UT code for WoS article

000581292300001

EID of the result in the Scopus database

2-s2.0-85091009161