Ex-Vivo 3D Cellular Models of Pancreatic Ductal Adenocarcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F25%3A00080191" target="_blank" >RIV/00209805:_____/25:00080191 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/25:00082324
Result on the web
<a href="https://journals.lww.com/pancreasjournal/fulltext/2025/01000/ex_vivo_3d_cellular_models_of_pancreatic_ductal.9.aspx" target="_blank" >https://journals.lww.com/pancreasjournal/fulltext/2025/01000/ex_vivo_3d_cellular_models_of_pancreatic_ductal.9.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MPA.0000000000002393" target="_blank" >10.1097/MPA.0000000000002393</a>
Alternative languages
Result language
angličtina
Original language name
Ex-Vivo 3D Cellular Models of Pancreatic Ductal Adenocarcinoma
Original language description
Pancreas is a vital gland of gastrointestinal system with exocrine and endocrine secretory functions, interweaved into essential metabolic circuitries of the human body. Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies, with a 5-year survival rate of 11%. This poor prognosis is primarily attributed to the absence of early symptoms, rapid metastatic dissemination, and the limited efficacy of current therapeutic interventions. Despite recent advancements in understanding the etiopathogenesis and treatment of PDAC, there remains a pressing need for improved individualized models, identification of novel molecular targets, and development of unbiased predictors of disease progression. Here we aim to explore the concept of precision medicine utilizing 3-dimensional, patient-specific cellular models of pancreatic tumors and discuss their potential applications in uncovering novel druggable molecular targets and predicting clinical parameters for individual patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pancreas
ISSN
0885-3177
e-ISSN
1536-4828
Volume of the periodical
54
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
"e57"-"e71"
UT code for WoS article
001375605100003
EID of the result in the Scopus database
2-s2.0-85212457568