Ex-vivo 3D cellular models of pancreatic ductal adenocarcinoma: from embryonic development to precision oncology

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F25%3A00080330" target="_blank" >RIV/65269705:_____/25:00080330 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00140267 RIV/00216208:11120/25:43927424
Result on the web
<a href="https://journals.lww.com/pancreasjournal/abstract/9900/ex_vivo_3d_cellular_models_of_pancreatic_ductal.188.aspx" target="_blank" >https://journals.lww.com/pancreasjournal/abstract/9900/ex_vivo_3d_cellular_models_of_pancreatic_ductal.188.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MPA.0000000000002393" target="_blank" >10.1097/MPA.0000000000002393</a>

Result language
angličtina
Original language name
Ex-vivo 3D cellular models of pancreatic ductal adenocarcinoma: from embryonic development to precision oncology
Original language description
Pancreas is a vital gland of gastro-intestinal system with exocrine and endocrine secretory functions, interweaved into essential metabolic circuitries of the human body. Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies, with a five-year survival rate of 11%. This poor prognosis is primarily attributed to the absence of early symptoms, rapid metastatic dissemination, and the limited efficacy of current therapeutic interventions. Despite recent advancements in understanding the etiopathogenesis and treatment of PDAC, there remains a pressing need for improved individualized models, the identification of novel molecular targets, and the development of unbiased predictors of disease progression. Here we aim to explore the concept of precision medicine utilizing three-dimensional, patient-specific cellular models of pancreatic tumors and discuss their potential applications in uncovering novel druggable molecular targets and predicting clinical parameters for individual patients.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30219 - Gastroenterology and hepatology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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