Prognostic significance of c-erbB-2 (HER-2/neu) oncoprotein and other parameters in benign and malignant breast tumor tissue

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F99%3A00000024" target="_blank" >RIV/00209805:_____/99:00000024 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Prognostic significance of c-erbB-2 (HER-2/neu) oncoprotein and other parameters in benign and malignant breast tumor tissue
Original language description
The overexpression of c-erbB-2 (HER2/neu) oncoprotein was analyzed quantitatively by ELISA in tissue extracts of benign and malignant breast tumors (N= 38 and 145, resp.). The level of this oncoprotein was above the cut-off value (100 kU/g protein) in 5%of dysplastic tissues and in 37 % of breast carcinomas (range 4.2-133.6 and 10.7-1862.9 kU/g protein, resp.). The correlation between c-erbB-2 measured by ELISA and detected semiquantitatively by immunohistochemistry was statistically significant. Dysplastic tissues with higher relative risk of malignant transformation were characterized by elevated c-erbB-2 values. In breast cancer patients, c-erbB-2 overexpression was inversely associated with disease-free interval. No correlation was found between c-erbB-2 and grading, lymph node infiltration, tumor size, or hormone receptor status.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
1999
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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