Quantitative analysis of c-erbB-2 oncoprotein in breast tumor tissue

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F99%3A00000075" target="_blank" >RIV/00209805:_____/99:00000075 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Quantitative analysis of c-erbB-2 oncoprotein in breast tumor tissue
Original language description
The study was designed to evaluate the prognostic importance of c-erbB-2 overexpression in breast cancer patients. In a retrospective study using breast tissue material we 1) analyzed quantitatively c-erbB-2 oncoprotein in breast cyst fluids of benign fibrocystic disease, in extracts of dysplastic tissues, fibroadenomas, phylloid tumors, and breast cancers, 2) we compared the results of the ELISA quantitative estimation with immunohistochemical localization, 3) we correlated these results with medicalhistory data, with available biochemical examinations, and with preliminary results of telomerase activity determinations as a measure of immortal character of tumor tissue. The c-erbB-2 oncoprotein expression differed significantly in benign and malignantbreast tumors,the highest concentrations were found in the breast cancer group (37% of malignant specimens were higher than cut-off value 100kU/g protein).The levels of this oncoprotein showed the inverse correlation with disease-free in
Czech name
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Czech description
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Publication year
1999
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
20th OECI Annual Scientific Meeting associated with 23rd Brno Days of Oncology and 13th Conference of Nurses
ISBN
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ISSN
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Number of pages
1
Pages from-to
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Publisher name
Masarykův onkologický ústav
Place of publication
Brno
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Event date
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Type of event by nationality
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UT code for WoS article
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