A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7144" target="_blank" >RIV/00216208:11110/10:7144 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains
Original language description
Endogenous retroviruses (ERVs) contribute to a range of mutations in mammals. However, autonomous retrotransposition of ERV has not been demonstrated in the rat genome. We cloned an insertion that disrupted Cntrob gene and identified it as a novel endogenous retrovirus (RnERV-K8e family). This family is closely related to the recently reported MmERV-K10c elements. We also identified a novel, unexpectedly close relative of RnERV-K8e in the mouse, suggesting cross-species transmission. We cloned a potentially autonomous RnERV-K8e element demonstrated that it is capable of retrotransposition. This particular element encodes an envelope gene (env), which is not required for retrotransposition. A number of RnERV-K8e-associated genetic polymorphisms was detected among inbred rat strains, suggesting ongoing activity in the rat genome. Ongoing retrotranspositional activity may significantly add to genomic variability among inbred rat strains.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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