Deltaretroviruses have circulated since at least the Paleogene and infected a broad range of mammalian species

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00520468" target="_blank" >RIV/68378050:_____/19:00520468 - isvavai.cz</a>
Result on the web
<a href="https://retrovirology.biomedcentral.com/articles/10.1186/s12977-019-0495-9" target="_blank" >https://retrovirology.biomedcentral.com/articles/10.1186/s12977-019-0495-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12977-019-0495-9" target="_blank" >10.1186/s12977-019-0495-9</a>

Result language
angličtina
Original language name
Deltaretroviruses have circulated since at least the Paleogene and infected a broad range of mammalian species
Original language description
The Deltaretrovirus genus of retroviruses (family Retroviridae) includes the human T cell leukemia viruses and bovine leukemia virus (BLV). Relatively little is known about the biology and evolution of these viruses, because only a few species have been identified and the genomic 'fossil record' is relatively sparse. Here, we report the discovery of multiple novel endogenous retroviruses (ERVs) derived from ancestral deltaretroviruses. These sequences-two of which contain complete or near complete internal coding regions-reside in genomes of several distinct mammalian orders, including bats, carnivores, cetaceans, and insectivores. We demonstrate that two of these ERVs contain unambiguous homologs of the tax gene, indicating that complex gene regulation has ancient origins within the Deltaretrovirus genus. ERVs demonstrate that the host range of the deltaretrovirus genus is much more extensive than suggested by the relatively small number of exogenous deltaretroviruses described so far, and allow the evolutionary timeline of deltaretrovirus-mammal interaction to be more accurately calibrated.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10607 - Virology

Project
<a href="/en/project/LO1419" target="_blank" >LO1419: Biomodels for Health - Center for model organisms</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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